Titration of free water

Posted: Juni 21, 2012 in Analist

Literature:  INDONESIA pharmacopoeia IV

METHOD I

Dissolve a test substance in a suitable volume of glacial acetic acid in the previous P neutralize against indicators as outlined in the monograph, if necessary in the warm and cooled, or bua solution as specified. If the test substance in the form of acid chloride or bromide salt, add 15 ml of mercury (II) acetate LP, unless otherwise stated in the monograph. Titration with 0.1 N perchloric acid until the color change indicator LV according to the absolute maximum dE / dV (E is the effect tromotif and V is the volume of titrant) in potentiometric titration. Indicators listed in the monograph are also used to neutralize the mercury (II) acetate LP and standardization of the titrant.

If the temperature at the time of the determination of the titrant (t2) is different from the temperature at the time of standardization of the titrant (t1), katalikan volume of titrant required by [1 + 0.0011 (t1 – t2)] and calculated from the corrected volume.

Potentiometric titration can be carried out using glass electrode and saturated calomel electrode comparison (certainly not a leak from the solution of the salt bridge) or use a combination electrode. The relationship between the calomel electrode and the titration liquid should have a sufficiently low electrical resistance and the displacement of fluid from one side to the other must be a minimum. The reading of the measurement results is less than zero can be avoided by using a stable electromotive resource in pairs in series with the electrode system. Instability can occur, if the connection elekterode potentiometers and system are not made in accordance with the manufacturer’s instructions.

METHOD II

Use the titrant, solvents and idikator as trtera the monograph.

Protect and titrant solution of carbon dioxide and moisture from the air during the determination.

Dissolve a test substance in a volume of a suitable solvent, which had previously been neutralized to the indicator, if need be warmed and cooled, or make a case that the solution is determined. Titration until the color change indicator in accordance with the maximum absolute rates dE / dV (E is the electromotive and V is the volume of titrant) in potentiometric titration. Titrant is standardized by using the same solvent and indicators as specified for the substance.

Potentiometric titration can be performed using a glass electrode and saturated calomel comparison, a saturated solution of chloride Kalim P in water was replaced with a saturated solution of potassium chloride in methanol P. P The relationship between the calomel electrode and the titration liquid should have a sufficiently low electrical resistance and the displacement of fluid from one side to the other must be a minimum. The reading of the measurement results is less than zero can be avoided by using a stable electromotive resource in pairs in series with the electrode system. Instability can occur, if the connection elekterode potentiometers and system are not made in accordance with the manufacturer’s instructions.

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