Tablet

Posted: Juli 8, 2012 in Analist, General monograph, Pharmacopoeia III, Pharmacopoeia IV

Literature: Indonesia Pharmacopoeia III,
Indonesia Pharmacopoeia IV

Compressi
Tablet

Indonesia Pharmacopoeia IV

 

Tablets are solid preparations containing the drug, with or without filler material. Based on the method of manufacture, can be classified as a tablet printing and tablet-felts.

Most of tablets prepared by compression and the dosage form is the most widely used. Tablet-felts are made with a high pressure on powders or granules using a steel mold. Tablets can be made any size, shape and tagging the surface depends on the design of the mold. Tablet is a capsule form generally called caplets. Bolus is a large tablet is used for animal drugs, usually for large animals.

Tablet print made by pressing damp powder masses with a low pressure into the mold holes. tablet density depends on the crystal bonds formed during the subsequent drying process does not depend on the strength of a given pressure.

Tritural Tablet is a tablet-shaped small print or felts, generally cylindrical, used to provide the right amount of measurable drug compounding. This type of tablet is now rarely used. Hypodermic tablet is a tablet-prints made from material that is easy to dissolve or dissolves perfectly in water, once commonly used to make hypodermic injection dosage. Given orally or if needed the rapid availability of drugs as well as in tablet nitroglycerin, given sublingual.

Buccal tablets use by placing the tablet between the cheek and gum and sublingual tablets use by placing under the tongue, so that the active substance is absorbed directly through the oral mucosa. Some drugs are easily absorbed in this method (such as nitroglycerin and certain sieorid hormones) and has many advantages.

Effervescent tablets that dissolve, made with felted manner, in addition to active substance also contains a mixture of acid (citric acid, tartaric acid) and sodium bicarbonate, which if dilarutakan in water will generate carbon dioxide. The tablet is dissolved or dispersed in water before administration. Efervensen tablets should be stored in tightly covered container or moisture resistant packaging, contained on the label does not profit directly ingested.

 

 

Compressi
Tablet

Pharmacopoeia III

Tablets are solid dosage compact, made of felt-print, in the form of flat tubes or circular, The second flat surfacesor convex, containing a single type of material or more drugs or without additives. Additives used can serve as fillers, substances developer, binder, lubricant agents, wetting substance or other suitable.

Coated tablets is a tablet that coated with a suitable coating agent for a particular purpose and objectives.
Tablet is tablet coated with a sugar solution or other suitable substance with or without dye.
Felts coated tablets is coated tablet in print with a mass granulat felts consisting of lactose, calcium fostat or other suitable substance.
Tablet membrane coated tablets is coated with a layer that is loaded by solvent deposition of a suitable solvent. Membrane layer is generally not more than 10% by weight of the tablet.
Enteric coated tablets is a tablet that coated with the coating substance is relatively insoluble in stomach acid, but soluble in alkaline environment and destroyed the small intestine.
Terms tablet, unless otherwise stated, the tablet must meet the following requirements:

Uniformity of size. Unless otherwise alin, tablet diameter of not more than 3 times and not less than one third thick tablet.
Uniformity of weight, coated tablets do not have to comply uniformity of weights assigned as follows: Weigh 20 tablets, calculate the average tablet weight. If you weighed one by one, no more than 2 tablets, each of which weighs mentimpang of weighted average of prices lebiah column A, and no one tabletpun weight deviates from the average weight of more than a set price column B.

Average weight

Deviation of the average weight
in%

≤ 25 mg

15%

30%

26 mg – 150 mg

10%

20%

151 mg – 500 mg

7,5%

15%

> 500 mg

5%

10%

Time of enteric coated tablets are not destroyed; tool long glass tube 80 mm till 100 mm, internal diameter ± 28 mm, outer diameter 30 mm to 31 mm, the lower end has a stainless wire mesh, the holes correspond to the number 4 sieve, basket-shaped.

Basket is inserted in the center hands of unidirectional glass tube diameter 45 mm, immersed in water temperature between 36º C and 38º C as much as ± 1000 ml, depth of not less than 15 cm so that will be subject to regular cuts. Position of the wire netting at the highest position just above the water surface and the position of the mouth of the basket just below the lowest surface of the water.

Method: 5 tablet input into the basket, pull up and down the basket on a regular basis 30 times per minute. Tablet otherwise destroyed if no part of the tablet is left on the screen, unless the fragments are derived from the coating substance. Unless otherwise stated, the time required to destroy the fifth tablet no more than 15 minutes for the tablets are not coated and not more than 60 minutes for coated tablets and sugar coated membrane.
If the tablet does not meet this requirement, repeat testing using the tablets one by one, then try again using a tablet with a 5 disc guide. By way of testing these tablets must meet the above conditions.

Guiding disc consists of a disc made of a suitable material, diameter ± 26 mm, 2 mm thick, flat bottom surface, the top surface with a distance of 3 holes each hole 10 mm from the center point. Each hole tersapat stainless wire diameter 0.445 mm, which is mounted perpendicular to the disc surface and connected by a ring made of a guide wire of the same type, diameter 27 mm. Distance above the surface of a ring guide discs 15 mm. The difference between the diameter of the guide disc in the basket, preferably between 1 mm and 2 mm. The weight of the guide disc no less than 1.9 grams and not more than 2.1 grams.

Guiding disc consists of a disc made of a suitable material, diameter ± 26 mm, 2 mm thick, flat bottom surface, the top surface with a distance of 3 holes each hole 10 mm from the center point. Each hole tersapat stainless wire diameter 0.445 mm, which is mounted perpendicular to the disc surface and connected by a ring made of a guide wire of the same type, diameter 27 mm. Distance above the surface of a ring guide discs 15 mm. The difference between the diameter of the guide disc in the basket, preferably between 1 mm and 2 mm. The weight of the guide disc no less than 1.9 grams and not more than 2.1 gram.Waktu enteric coated tablets destroyed; Perform the test of time destroyed using the tools and the manner mentioned above the water, replaced with 250 ml ± 0.06 N acid kloroda . The work carried out for 3 hours, unless the substance is not soluble tablet coating. Immediately wash basket tool tablets with water. Replace the acid solution with pH 6.8 buffer, set the temperature between 36ºand 38º. Dip the basket into the solution. Continue testing for 60 minutes. At the end of the tablet there is no testing on the screen except the fragments of coating substances.
If the tablet does not meet this requirement, repeat testing using the tablets one by one, then try again using a tablet with a 5 disc guide. With a method of testing these tablets must meet the above conditions.

Storage: In tightly sealed container in a cool place, protected from light.

 

 

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